12/18/2023 0 Comments Med sci monit impact factorCONCLUSIONS AE might serve as a candidate in the treatment of colorectal cancer through inducing ER stress-dependent apoptosis. CHOP and caspase-12 are important regulatory factors leading to cell apoptosis. Meanwhile, we detected an increased cytosolic calcium content followed by the upregulation of the calpain-1, calpain-2 and caspase-12. We found that cells exposure to AE had upregulation of unfolded protein response (UPR) proteins like glucose-related protein 78 (GRP78), phosphorylated protein kinase R (PKR)-like ER kinase (p-PERK), phosphorylated eukaryotic initiation factor-2α (p-eIF2α), and transcription factor C/EBP homologous protein (CHOP). We then detected the expression of ER stress-related proteins and cytosolic calcium levels. Furthermore, both cell lines when exposed to AE generated ROS, which induces endoplasmic reticulum (ER) stress. More Medical Science Monitor Journal's Impact Trend, Prediction, Ranking & Key Factor Analysis are all in Acadmeic Accelerator. On the other hand, Impact Score is based on Scopus data. RESULTS Our results indicated that AE suppressed cell viability and induced cell apoptosis in SW620 and HT29 cell lines. The Medical Science Monitor Latest Journal's Impact IF 2021-2022 is 2.649. Scope Medical Science Monitor Basic Research is an international, peer-reviewed scientific journal that publishes original articles in basic, clinical, and related biomedical disciplines such as epidemiology, public health, and medical technology. The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as indexed by Clarivates Web of Science. After treatment with various concentrations of AE (10, 20, and 40 μM), cell proliferation, cell apoptosis, reactive oxygen species (ROS) generation, cytosolic calcium level, and related gene expression were analyzed. MATERIAL AND METHODS In this study, we examined the impact of AE on SW620 and HT29 colorectal cancer cell lines. Whether AE exerts an effect on colorectal cancer cells has not yet been investigated. Aloe-emodin (AE), a natural compound extract from Aloe Vera, has been discovered to suppress cell proliferation and accelerate apoptosis in a variety of tumor cells. Research has reported that several kinds of single compounds of Chinese herbs have shown anti-tumor activity in colorectal cancer. BACKGROUND Recently, colorectal cancer has become a more common type of tumor in the world.
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